NF1 and malignant peripheral nerve sheath tumor: Importantly, individuals with NF1 microdeletions have a lifetime MPNST risk in the range of 16–26% [18, 24], which is higher than the estimated lifetime MPNST risk in the general NF1 population of 8–13% according to Evans et al. [25, 26] or 15.8% according to Uusitalo et al. [27].