HTR1A and Anxiety: In this study, our aim was to investigate the effects of perinatal FLX treatment on (1) circadian rhythms for both body temperature and activity, including phase shifts in response to photic (light) and nonphotic cues such as the 5-HT1A/7 agonist 8-OH-DPAT, (2) the sensitivity to 5-HT1A receptor agonist induced hypothermia, (3) anxiety and stress coping behavior, and (4) gene expression levels of the 5-HT1A receptor and clock genes in the SCN.