SHBG and type 2 diabetes mellitus: We observed little evidence of association between SHBG and self-reported doctors-diagnosis of diabetes (field ID 2443, P = 0.368) or self-reported type-2 diabetes (field ID 20002, value code #1223, P = 0.454) in the MR-pheWAS, despite prior observational and genetic evidence of a protective effect (8, 9, 36, 37).