To further elucidate TME features of immune-competent subtypes in 7 different types of cancer, we compared the estimated abundances of infiltrated immune cells, including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages and dendritic cells (DC) from TIMER, which were appropriate for inter-sample comparison and validated using multiple approaches14,18. This evidence concerns the gene CD4 and cancer.