NRAS and melanoma: We investigated the IRAK-M DNA methylation profiles of patient samples and melanoma cell lines and found that reduced methylation within the promoter region of IRAK-M correlated with increased transcript levels (Fig. 1f, Supplementary Fig. 3b, c), neither did they correlate with BRAF or NRAS mutation status, nor CDKN2A genotype (Supplementary Fig. 3b).