We investigated the IRAK-M DNA methylation profiles of patient samples and melanoma cell lines and found that reduced methylation within the promoter region of IRAK-M correlated with increased transcript levels (Fig. 1f, Supplementary Fig. 3b, c), neither did they correlate with BRAF or NRAS mutation status, nor CDKN2A genotype (Supplementary Fig. 3b). This evidence concerns the gene CDKN2A and melanoma.