Additionally, conserved domains (CD) were predicted in APMV-1 mesogenic strain Komarov (CD between aa 25 to 167) for large tegument protein UL36 (superfamily member PHA03247), in APMV-14 (CD between aa 31 and 144) for gene regulated by oestrogen in breast cancer- GREB1 (superfamily member, pfam15782) and in APMV-21 (CD between aa 53 and 120) for Tumor necrosis factor receptor superfamily member cd13415. The gene discussed is LARGE1; the disease is breast carcinoma.