NRG2 and cancer: Future work should investigate the role of TrkB.T1 in PI3K/Akt pathways and PI3K/ERBB2/ERBB3/ERBB4 networks across various cancer types, as western blots (corresponding to RNASeq data) show upregulation of ERBB3 receptor in TrkB.T1 transduced NCS, along with increased expression NRG2, a ligand for ERBB3 and ERBB454 (Supplementary Fig. 9c).