As mentioned above, in addition to endocytic and vesicular compartment GO terms (as shown in Fig. 3 and Supplementary Data 4), DGCA GO analysis for positive NTRK2 correlations in glioma reactome pathways revealed enrichment for genes in the PI3K and mTOR signaling pathways (Fig. 3d and Supplementary Data 4), which have been known to regulate cellular proliferation in normal and oncogenic contexts. The gene discussed is NTRK2; the disease is glioma.