Predominant TrkB.T1 expression in gliomas (Fig. 2, Supplementary Data 2) combined with GO enrichment analysis data showing altered genesets involved in endocytic trafficking in brain tumors compared with normal brain (Fig. 3) suggested that TrkB.T1 localization may be altered in LGG and GBM. This evidence concerns the gene NTRK2 and brain neoplasm.