Predominant TrkB.T1 expression in gliomas (Fig. 2, Supplementary Data 2) combined with GO enrichment analysis data showing altered genesets involved in endocytic trafficking in brain tumors compared with normal brain (Fig. 3) suggested that TrkB.T1 localization may be altered in LGG and GBM. The gene discussed is NTRK2; the disease is central nervous system cancer.