Given the differences in TrkB.T1 expression and distribution in normal brain and gliomas in both humans and mice, we sought to explore the role of TrkB.T1 in glioma biology utilizing the RCAS/tv-a system, which allows somatic transfer TrkB.T1 into specific cell types of genetically altered mice40,41. This evidence concerns the gene NTRK2 and central nervous system cancer.