Under the treatment of ionizing radiation (IR), the phosphorylation of PTEN at 240 sites facilitates the interaction between pY240-PTEN and Ki-67, which promotes the recruitment of RAD51 to accelerate DNA repair.392 In glioblastoma (GBM) preclinical model, blocking Y240 phosphorylation can enhance radio sensitivity and prolong survival and Y240F-PTEN knock in mice showed radio sensitivity. The gene discussed is MKI67; the disease is glioblastoma.