TP53 and neoplasm: Similar to MDM2, Trim24 controls p53 levels in an autoregulatory feedback loop.297 However, unlike MDM2, Trim24 also terminates the activated p53-regulated response upon DNA damage.296 p53 is ubiquitinated and negative regulated by Trim24, which indicated that Trim24 is a therapeutic target for p53 to restore tumor inhibition.