Cytosolic p53 performs a non-transcriptional function by interacting with, and then counteracting, the anti-apoptotic function of Bcl (B cell lymphoma/leukemia)-2.220 In addition, p53-Bcl-2 binding depends on p53 SUMOylation,221 and a lot of cytoplasmic p53 localization is clinically associated with poor prognosis and disease progression to hormone-resistance status.222. This evidence concerns the gene TP53 and leukemia.