Indole-3-methanol, a compound discovered in cruciferous vegetables, as a natural and effective WWP1 inhibitor.415 Further, linc02023 specifically interacts PTEN, and inhibits its interaction and ubiquitination with PTEN through WWP2, making it stable and inhibiting its downstream expression, suggests that linc02023 may be a new therapeutic target by restoring the antitumor activity of PTEN.416 Therefore, it is a potential therapeutic strategy for the prevention and treatment of cancer through via activation of PTEN. Here, WWP2 is linked to cancer.