The mouse model demonstrated the tumor promoting effect of deletion of Rb, Pten, or p53 in fibroblasts, which transformed normal fibroblasts into cancer-related fibroblasts.71 The above suggests the interaction of signaling pathways managed through tumor suppressors, and those three major tumor suppressor genes interact with each other in the development and progression of these tumors, and PTMs play an important role in it. This evidence concerns the gene RB1 and cancer.