The caspase 8/10-associated RING proteins (CARPs), CARP1 and CARP2, act as RING-domain E3 ligases that target apical caspases for proteasome-mediated degradation.304 In addition to apical caspases, CARPs, which are overexpressed in cancer, physically interact with and target p53 or phospho-p53 for ubiquitination and degradation with or without MDM2. This evidence concerns the gene MDM2 and cancer.