TP53 and cancer: Interestingly, lysine-specific demethylase 1 (LSD1) selectively wipes off this second methyl group, thus inhibiting p53 function by interrupting the association of p53 with 53BP1, which contributes to these effects.207,208 Thus, p53 contributes to keep DNA methylation homeostasis and clone homogeneity, which may benefit to its anti-cancer activity.