RB1 and retinoblastoma: In fact, experiments about somatic cell fusion or chromosome separation have shown the presence of genes that inhibit tumorigenicity.4 Carcinogenesis is a very complicated process, which can be attributed to either mutation of oncogene function or tumor suppressor gene (TSGs).5 Our understanding of TSGs mostly comes from the preliminary study of retinoblastoma genes, the first discovery of a TSG, and mutation causes retinoblastoma in children.6,7 This is a genetic disease caused by the retinoblastoma susceptibility gene (Rb1) gene inactivation mutation.