There are data indicate that serine 23 phosphorylation response to DNA damage contributes to the stabilization of p53 protein and cell type dependence of p53-dependent apoptosis, as well as to inhibit the occurrence of B-cell lymphoma.355 p53HupKIS46A, a HupKI mouse strain with serine 46 mutated to non-phosphorylatable alanine, was established to study the role of serine 46 phosphorylation in vivo.356,357 This residue plays a major role in p53-mediated apoptosis. Here, TP53 is linked to B-cell non-Hodgkin lymphoma.