MDM2 and cancer: Moreover, USP10 is mainly localized in the cytosol, where its function is to maintain the levels of p53 and to counteract MDM2-mediated p53 nuclear export under normal conditions.330 Upon DNA damage, USP10 is phosphorylated by ATM, after which it is re-localized to the nucleus where p53 de-ubiquitination occurs, which is the reverse of the function of residual MDM2, which ubiquitinates p53.329,330 As USP10 plays an anti-cancer role by regulating the nuclear output and degradation of p53 induced by MDM2, down regulating DUBs may have an impact on cancer and other hypoxia related diseases.331