Downregulation or upregulation of circZNF566 respectively decreased and increased the protein and mRNA expression of Bcl-2, Ki67, N-cadherin, Caspase, and Vimentin, and the protein and mRNA expression of E-cadherin was opposite in HCC cells (Fig. 7d, e, Supplementary Fig. 6b, c). This evidence concerns the gene CDH2 and hepatocellular carcinoma.