In addition, knockdown of linc-VLDLR reduced ABCG2 (ATP binding cassette, subfamily G member 2) expression, and overexpression of this protein reduced the effect of linc-VLDLR knockdown on sorafenib-induced cell death.67 Apart from lncRNAs, miRNAs can also be carried in exosomes, and miR-122-transfected adipose tissue mesenchymal stem cells (AMSCs) have been shown to efficiently package miR-122 in secreted exosomes, probably mediating AMSC and HCC cell miR-122-related communication processes, thus making HCC cells sensitive to sorafenib by altering the expression of miR-122 target genes. This evidence concerns the gene VLDLR-AS1 and hepatocellular carcinoma.