Small nucleolar RNA host gene 3 (SNHG3) had significantly higher expression in highly metastatic HCC cells than in poorly metastatic HCC cells and induced epithelial–mesenchymal transition (EMT) through miR-128/CD151 cascade activation to produce sorafenib resistance.28 SNHG16 was reported to be upregulated in HepG2 sorafenib-resistant (SR) cells, and SNHG16 knockdown increased the sensitivity of HepG2 SR cells to sorafenib in vitro and in vivo. This evidence concerns the gene SNHG16 and hepatocellular carcinoma.