BECN1 and hepatocellular carcinoma: A recent study has shown that ADRB2 signaling restrained autophagy through disruption of the Beclin1/VPS34/Atg14 complex in an AKT-dependent manner, causing HIF1α stabilization, reprogramming of glucose metabolism in HCC cells, and sorafenib resistance in DEN-induced HCC mouse models.82 Despite ample evidence that targeted autophagy processes represent potential therapeutic interventions for HCC (Fig. 3), there are many unresolved issues related to autophagy in sorafenib resistance.