Tumor cells dictate immunosuppressive components (immune cells such as Treg cells, M2 macrophages, and myeloid-derived suppressor cells (MDSCs) as well as cytokines including TGF-β and IL-10) to orchestrate an immunosuppressive TME, which restrains entry and activity of the effector T cells and hinders ICT (Fig. 1). Here, TGFB1 is linked to neoplasm.