POU4F1 and melanoma: We regulated the expression of POU4F1 by using overexpression plasmids and POUF41 shRNAs (overexpressing and interfering efficiencies shown in Fig. 3c) and found that the overexpression of POU4F1 promoted the resistance to Vemurafenib in both parental and resistant cells, while the down-regulation of POU4F1 sensitized melanoma cells to Vemurafenib (Fig. 3d).