The presence or absence of cGAS orthologs seems to make no difference in the mortality rates resulting from infections by Listeria or DNA viruses, such as invertebrate iridescent virus 6 (IIV6), in Drosophila. 48 Therefore, the exact function of cGAS orthologs in Drosophila, as well as how cGAS has gained its role in antiviral immunity throughout evolution, remains to be determined. The gene discussed is CGAS; the disease is infection.