CGAS and cancer: On the one hand, cytokines, such as type I IFN, induced by the activated cGAS-STING pathway boost natural killer (NK) cell responses and prime CD8+ T cells for a more potent tumour surveillance.148,151 In addition, the activation of the cGAS-STING pathway leads to the induction of a set of senescence-associated secretory phenotype (SASP), which amplifies cell senescence, thereby restricting tumourigenesis.152,153 On the other hand, the activation of cGAS and STING has been linked to metastasis and immune evasion in cancers.