CGAS and infection: As a key PAMP during infections, pathogen DNA that localises in abnormal cell sites, such as the cytosol and endosomes, alerts DNA sensors to trigger downstream innate immune responses.1,2 To date, multiple DNA sensors have been identified, among which cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) represents an essential one.3,4