CGAS and viral infectious disease: It has been shown that K48-linked polyubiquitination of cGAS facilitates cGAS degradation via the p62-mediated autophagy or proteasome pathway.85,102 The E3 ubiquitin ligase RNF5 and TRIM30α interact with STING and catalyse its polyubiquitination with K48-linked polyubiquitin chains after viral infection.