Notably, another study underscored that Hantaan virus, the pathogen of hemorrhagic fever with renal syndrome (HFRS), promotes the secretion of CXCL10 by facilitating NF-κB and IRF7 to directly bind to the promotor of CXCL10 in the downstream of MDA569. The gene discussed is IRF7; the disease is hemorrhagic fever with renal syndrome.