In vitiligo, the excessive CXCL10 (chemokine (C-X-C motif) ligand 10)43,44 and CXCL1645 in epidermis have been established to play key roles in the skin trafficking of autoreactive melanocyte-specific CD8+ T cells1, which has been recognized as the main cause of melanocyte death in vitiligo. The gene discussed is CXCL10; the disease is vitiligo.