Hence, the robust inhibitory action of RXFP3 activation on the activity of OXT and AVP MNCs in PVN documented here and elsewhere (Kania et al., 2017), together with the reduced PVN c-fos mRNA levels observed in BE females (Lenglos et al., 2013) and the RXFP3 activation-dependent reduction of OXT and AVP mRNA expression (Ganella et al., 2013a), point to strong inhibition of PVN OXT and AVP signaling during BE episodes. Here, OXT is linked to Barrett esophagus.