RLN3/RXFP3 signaling has been linked to binge-like eating (Lenglos et al., 2013; Calvez et al., 2016b); so to further assess the involvement of PVN RXFP3 in this phenomenon, we used an established rat model of BE (Cifani et al., 2009; Piccoli et al., 2012; Micioni Di Bonaventura et al., 2017) combined with intra-PVN injections of the RXFP3 antagonist, R3(B1-22)R. This evidence concerns the gene RLN3 and Barrett esophagus.