RLN3 and eating disorder: Notably, RLN3-synthesizing neurons are highly stress-responsive (Tanaka et al., 2005; Ma et al., 2013), which together with sex differences in RLN3 actions (for review, see Calvez et al., 2017) and the involvement of RXFP3 in BE behavior modulation shown here, provide a strong rationale for investigating the role of RLN3/RXFP3 signaling in the development of stress-related psychiatric conditions (Kumar et al., 2017), particularly in stress-related eating disorders that differentially affect men and women.