Hence, the robust inhibitory action of RXFP3 activation on the activity of OXT and AVP MNCs in PVN documented here and elsewhere (Kania et al., 2017), together with the reduced PVN c-fos mRNA levels observed in BE females (Lenglos et al., 2013) and the RXFP3 activation-dependent reduction of OXT and AVP mRNA expression (Ganella et al., 2013a), point to strong inhibition of PVN OXT and AVP signaling during BE episodes. The gene discussed is AVP; the disease is Barrett esophagus.