A recent study showed that T cell death-associated gene 51 (TDAG51) knockout, microglia-specific autophagy-deficient mice combined with chronic unpredictable mild stress during gestation also can induce depression-related behaviors in the female mice after parturition also support the fact that certain functional genes indeed can affect the behaviors in the postpartum female mice [12, 50]. Here, PHLDA1 is linked to major depressive disorder.