The objective of this review was to evaluate the accuracy of maternal blood inflammatory markers: C-reactive protein (CRP), procalcitonin (PCT) and interleukin 6 (IL6) in the diagnosis of histologic chorioamnionitis and/or funisitis in PPROM and to assess the sources of heterogeneity in estimates of diagnostic accuracy. The gene discussed is IL6; the disease is preterm premature rupture of the membranes.