In addition, we have shown that MS promotes the development of endometriosis and exacerbates endometriosis-associated generalized hyperalgesia in adult female mice, likely through decreased DRD2 expression and activation of the ADRB2/CREB signaling pathway, leading to increased angiogenesis and progression of endometriotic lesions. The gene discussed is CREB1; the disease is myeloid sarcoma.