Consequently, catecholamines, such as epinephrine and norepinephrine, resulting from chronic stress would activate the cAMP/protein kinase A (PKA) signaling pathway, which in turn results in the phosphorylation of the CREB family [58] that is known to be involved in steriodogenesis in endometriosis [59]. This evidence concerns the gene CREB1 and endometriosis.