The most of up- or down-regulated genes were not common CRC driver genes except NOTCH3 and MYH11. Collagen-associated genes, including COL1A1, COL5A1, COL18A1 and COL9A3 were examined in top 10 up- or down-regulated genes (Fig. 4a, b), which attributed to less stoma composition in xenografted liver metastases than that of matched donor. The gene discussed is NOTCH3; the disease is colorectal carcinoma.