Compared to other NMD such as Myasthenia gravis (14,950€) [15], CMT (17,427€) [43], facioscapulohumeral muscular dystrophy (26,240€) [15] and BMD (39,060€) [17] total COI of ALS is notably higher, similar to those of DMD (78,913€) [17] and SMA (70,566€) [18]. This evidence concerns the gene SMN1 and amyotrophic lateral sclerosis.