Therefore, taking into consideration the potential neuroprotective and anticonvulsive effects of IL-10 [4], we performed this study to examine the role of circulating IL-10 in patients with refractory TLE with hippocampal sclerosis (TLE + HS), TLE without HS (TLE-HS) and other epilepsies. This evidence concerns the gene IL10 and histiocytic sarcoma.