Secondly, there exists a paucity of new data regarding CrAg positivity prevalence, CM incidence, and all-cause mortality in HIV-infected persons with CD4+ T-cell counts< 200 cells/μL since 2015 [27], and our pooled outcome analyses relied heavily on older studies, which may be less applicable to the modern test-and-treat era. The gene discussed is CD4; the disease is cutaneous mastocytosis.