The risk factors in ACS group was respectively overweight (64.10%), hypertension (49.88%), hyperlipidemia (40.72%), diabetes (23.37%), depression or anxiety disorder (16.63%), gynecological diseases (16.39%), hyperuricemia (14.94%), family history of early- onset coronary heart disease (14.94%), hyperhomocysteinemia (11.33%), low thyroid function (9.46%), high cholesterol (8.43%), high CRP (7.47%). This evidence concerns the gene CRP and major depressive disorder.