The confidence interval of 95% of relative risk (RR) was respectively hyperlipidemia (12.21—46.94), high homocysteine (Hcy, 5.32—43.76), overweight (4.95—11.07), high CRP (3.22—35.82), high blood pressure (2.80—6.87), low thyroid function (2.79—31.13), gynecological diseases (2.59—14.23), depression or anxiety (2.40—12.71), cardiac insufficiency (2.25—155.03), Hypercholesterolemia (2.23—12.21), diabetes (2.14—7.96), oral contraceptive (2.08—65.58), family history of early-onset CHD (1.66—9.86), and autoimmune diseases (1.60—22.75) (P < 0.01). The gene discussed is CRP; the disease is Anxiety.