In addition to the four traditional risk factors of hypertension, hyperlipidemia, smoking, and diabetes, the regression analysis results showed that in young women, hyperhomocysteinemia, overweight /obesity, high CRP, hypothyroidism, gynecological diseases, depression or anxiety, cardiac insufficiency, and oral contraceptives, family history of early-onset CHD and autoimmune diseases are independent risk factors. This evidence concerns the gene CRP and female reproductive system disorder.