In a randomized, double-blind trial, Lee et al. [25] found that patients with hypoalbuminemia administered 20% human albumin before the operation demonstrated a lower incidence of postoperative AKI than those administered an equal volume of saline (13.7% vs. 25.7%; RR (95% CI) = 0.533 (0.296–0.961); P = 0. The gene discussed is ALB; the disease is acute kidney injury.