LEP and Peritoneal Fibrosis: As summarized in this review, tamoxifen has multiple mechanisms of action, including the inhibition of TGF-β1 targets, ERE and HRE, HIF-α, SNAIL, RAGE, VEGF, MMP, PAI-I, Leptin, PARP, peritoneal fibrosis, platelet activation, cell migration, BM/ECM invasion, and neoangiogenesis.