This is mediated by TGF-β1 release, k-ras and p53 expression, cancer cell secretion of exosomal hydrogen peroxide and IL-6, loss of caveolin-1 and induction of CAF oxidative stress, HIF-1α, NF-κB and autophagy [1,9,30,36]. The gene discussed is TGFB1; the disease is cancer.