TGFB1 and gastric cancer: The 2015 consensus molecular subtype (CMS) classification of colorectal cancer [38]; and the 2015 Asian Gastric Cancer Research Group classification of gastric cancers [39] identified certain epithelial cancer subtypes with stable genomes, but with mesenchymal properties characterized by abnormal TGF-β1 signaling and a predilection for peritoneal spread and poor prognosis.