In angiosarcoma cells, the most downregulated genes were: DNA binding protein; Endonuclease/Exonuclease/Phosphatase Family Domain-Containing Protein 1 (Eepd1), micro-satellite locus Atplb2, muscle chloride channel (Clcn1), channel regulating excitability of muscle tissues; potassium voltage-gated channel subfamily J member 2 (Kcnjll) and basic helix-loop-helix-leucine zipper transcriptional activator; Transcriptional Activator MondoA (Mlxip). This evidence concerns the gene CLCN1 and angiosarcoma.