At the same time, the most upregulated genes in angiosarcoma were DNA helicase, essential for genomic DNA replication: Minichromosome Maintenance Complex Component 2 (Mcm2), intracellular transport of proteins coat complex II component (Sec23b), sub-apical actin network organizing protein; Rho GTPase Activating Protein 42 (Arhgap42), glycogen metabolism regulator; Acetylglucosamine Phosphomutase (Pgm3) and promoting cell motility with stress fibers; Calponin 3 (Cnn3) (Figure 4f). The gene discussed is PGM3; the disease is angiosarcoma.