TIE1 and angiosarcoma: Moreover, typical angiosarcoma-related genes have shown an overexpression trend confirming the histopathologic profile of the analyzed tumors—tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie1), Fms-related tyrosine kinase 4, (Flt4), Fli-1 Proto-Oncogene (Fli1), ephrin type-A receptor 2 (Epha2), placental growth factor (Pgf), BHLH transcription factor (Myc) and Endothelin receptor type B (Ednrb) (Figure S8).