These data suggest that the TOR and AKH pathways, as well as the lipid transport, are involved in the reduction of BPH fecundity after Nlug-desatA2-knockdown and that Nlug-desatA2 knockdown did not influence the transcript level of JH pathway-related genes, JHAMT, JHE and Met in BPH. The gene discussed is HJV; the disease is benign prostatic hyperplasia.