NRAS and melanoma: When we compared in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays the effect of SB202190 and SB590885 on the proliferation of a panel of melanoma cell lines, as expected, we observed that BRAF-mutated melanoma cell lines were more sensitive to the compounds than NRAS-mutated melanoma cells (Figure S3).