Interestingly, although there are no telomere-related effects of PTBP1 knockdown on the NOVA1-negative NSCLC line Calu6, overexpression of NOVA1 in Calu6 cells restores the capacity of PTBP1 knockdown to shift hTERT splicing towards the -β variant and reduce telomerase enzyme activity. The gene discussed is PTBP1; the disease is non-small cell lung carcinoma.