Based on our results, we propose that the findings in the schizophrenia-like behavioral phenotype of SREBP1-c KO mice are closely linked to the differential gene expression of Glp2r, Ndn, Il1r1, Erbb4, and Aox4, which possibly results in changes in signaling transduction, cell differentiation, and cell survival within the hippocampal cell population. This evidence concerns the gene SREBF1 and schizophrenia.