This provides interesting evidence that supports the involvement of ERBB4 signaling in the hippocampus of SREBP-1c KO mice that exhibit schizophrenia-like behaviors; however, further studies are needed to confirm the specific role of ERBB4 signaling in hippocampal lipid homeostasis of SREBP-1c KO mice. The gene discussed is SREBF1; the disease is schizophrenia.