Recently, we found that the deficiency of SREBP-1c induces schizophrenia-like behavior in mice [15], and further explore the mechanisms involved in these behavioral aberrations, we sought to identify differentially expressed genes (DEGs) in the hippocampus of SREBP-1c knockout (KO) mice compared to in that of wild type (WT) littermates. This evidence concerns the gene SREBF1 and schizophrenia.