CREBBP and melanoma: Although mitogen-activated protein kinase (MAPK) signaling regulates MITF nuclear export (Ngeow et al., 2018) and enhances interaction with the transcription cofactor CREB-binding protein (CBP)/p300 (Price et al., 1998), how the deregulated BRAF or NRAS signaling that drives melanoma progression otherwise affects MITF’s capacity to regulate gene expression is poorly understood.