MITF (Goding and Arnheiter, 2019), a lineage survival oncogene (Garraway et al., 2005), coordinates differentiation, regulates proliferation, suppresses migration/invasiveness and tumor-initiation capacity, and controls lysosome biogenesis, autophagy, and drug sensitivity (Carreira et al., 2005, Carreira et al., 2006, Cheli et al., 2011, Dugo et al., 2015, Hoek et al., 2008, Konieczkowski et al., 2014, Müller et al., 2014, Ploper et al., 2015, Zhang et al., 2015, Möller et al., 2019). The gene discussed is MITF; the disease is neoplasm.