Eight of those (SCN1A, IQSEC2, STXBP1, CACNA1E, ARID1B, DDX3X, WHSC1, PHF21A) have been known to be responsible for NDDs associated with IDs or epilepsies.9, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29. Here, IQSEC2 is linked to epilepsy.