In terms of the transcriptome, RA synovial fluid macrophages express pro‐inflammatory genes (INHBA, FCER1A, SLC2A1, MMP12, EGLN3 and CCR2), while exhibiting a low expression of anti‐inflammatory genes (IGF1, HTR2B, FOLR2 and CD36). The gene discussed is MMP12; the disease is rheumatoid arthritis.