Moreover, among patients with EGFR (OMIM 131550)/ALK (OMIM 105590)–negative NSCLC, MUC16 variation was associated with longer PFS (HR, 0.45; 95% CI, 0.29-0.70; P < .001) (Figure 2C) and OS (HR, 0.30; 95% CI, 0.11-0.80; P = .01) (Figure 2D). The gene discussed is ALK; the disease is non-small cell lung carcinoma.