To further prove that resveratrol inhibits the malignant progression of HCC via MARCH1-induced regulation of the PTEN/AKT signaling pathway, the PTEN inhibitor BPV(phen) and the p-AKT inhibitor MK2206 combined with resveratrol were used to treat HepG2 cells and then analyzed the changes and correlation of these related genes expression. This evidence concerns the gene PTEN and hepatocellular carcinoma.