In contrast, an ongoing, phase II trial with trastuzumab deruxtecan in advanced gastric/GEJ carcinomas (DESTINY-Gastric01) enrolled only those patients whose cancers were HER2-positive (Score 3+ by IHC or 2+ IHC with confirmatory HER2 amplification by in situ hybridization assay). Here, ERBB2 is linked to cancer.