Due to the involvement of the LZ2 helix in both APOL1 cis‐interactions and SRA binding, LZ2 mutations designed to avoid APOL1 neutralization by SRA (G1 and G2) also implied some reduction of cis‐interactions, progressively triggering trans‐interactions with APOL3 and APOL3 inactivation, hence kidney disease. Here, APOL3 is linked to kidney disorder.