A large number of mutations of human ASMT gene have been screened to determine candidate alleles with some mental diseases, such as intellectual disability (Pagan et al., 2011), attention‐deficit/hyperactivity disorder (Chaste et al., 2011), bipolar disorder (Etain et al., 2012), autism (Jonsson et al., 2010; Wang et al., 2013). Here, ASMT is linked to bipolar disorder.