PLIN5 and type 2 diabetes mellitus: PLIN5 protein quantification in individual lipid droplets should be performed concomitantly with lipid droplet–mitochondrial interaction analyses in athletes and in those with type 2 diabetes upon an acute exercise bout to gain a better understanding of how lipid droplet–mitochondrial tethering works and if the capacity to tether additional mitochondria to lipid droplets upon exercise is compromised in individuals with type 2 diabetes (Fig. 1).