KLK3 and Familial prostate cancer: Ki = 65 nM. 60 times more selective compared to chymotrypsin (Ki = 3.9 μM). Reduction in free and total KLK3 serum levels in human prostate cancer xenografts produced in nude mice upon intravenous administration of 33 mg/kg dose for two cycles of three consecutive days/5 days [128]