Multiple additional targets of miR-224 have been identified that may promote tumor cell proliferation and metastasis, including the cyclin-dependent kinase p21, SMAD4, PPP2R1B, TRIB1, RKIP, API5, CDC42, PAK2, and CDH1 [reviewed in Chen et al. (40)]. The gene discussed is SMAD4; the disease is neoplasm.