In silico analysis of deposited high-throughput sequencing and crosslinking immunoprecipitation (HiTS-CLIP) experiments of human Argonaute (AGO) in hepatocellular carcinoma cells [GSE64680 (31)] confirmed AGO2 occupancy at predicted miR-224 and miR-520d response elements in the 3′-UTRs of PCSK9, IDOL, and HMGCR (Supplementary Figures 2–4). The gene discussed is FBXW7; the disease is hepatocellular carcinoma.