Previous experiments by our group showed that metabolism-related genes, including aldo-keto reductase family 1, member b1 (AKR1B1) (71), methionine adenosyltransferase 1a (MAT1A) (72), and chromosome 19 open reading frame 80 (C19orf80) (73), upregulated by T3 in TR-overexpressing HepG2 cells, modulated HCC progression. The gene discussed is AKR1B1; the disease is hepatocellular carcinoma.