TENT5A and cancer: Previous genetic and proteomic analyses in mutant mice and human patients as well as in vivo manipulation in Xenopus have provided definite evidences for a role of FAM46A in metabolic pathways, embryonic and bone development, as well as cancer and retinal diseases (Lagali et al., 2002; Cui et al., 2006; Barragan et al., 2008; Etokebe et al., 2015b; Diener et al., 2016; Carayol et al., 2017; Doyard et al., 2018; Watanabe et al., 2018).