TNFRSF1B and colitis: Indeed, TNFR2 expression by CD4+ Teffs is required to induce full-fledged experimental colitis, based on a defective proliferative expansion of TNFR2-deficient Teff cells, as well as their reduced capacity to mount a full-fledged proinflammatory Th1 cytokine response (Chen et al., 2016).