TNFRSF1B and glycogen storage disease VI: Interestingly, using the EAE immunization mouse modelseveral independent groups showed that TNFR1–/–-mice do not develop EAE motor disease, whereas TNFR2 deficiency resulted in an exacerbated form of EAE (Eugster et al., 1999; Suvannavejh et al., 2000; Kassiotis and Kollias, 2001; Williams et al., 2014), indicating opposing roles of the TNFRs in EAE.