Tumor necrosis factor also plays an important role for the development of chronic neuropathic pain (CNP), a long-lasting chronic pain that is caused by damage to the somatosensory nervous system and is associated with various diseases/conditions, including neurodegenerative and inflammatory diseases, diabetes, cancer and chemotherapy (Scholz and Woolf, 2007; Murphy et al., 2017). Here, TNF is linked to cancer.