Similarly, bispecific antibodies could be used to retarget the TNFR2 binding site and to induce a multivalent presentation, as shown for a tetravalent bispecific anti-TRAILR2 antibody targeting fibroblast activation protein (FAP) on tumor stroma fibroblasts (Brünker et al., 2016). Here, TNFRSF1B is linked to neoplasm.