TNF and arthritic joint disease: It was first shown in 2007 that sTNF neutralization attenuates experimental arthritis in two rodent arthritis models without suppressing innate immunity to Listeria infection (Zalevsky et al., 2007), indicating that inflammation in mouse arthritis models is primarily driven by sTNF, and suggest that sTNF inhibitors might have a superior safety profile compared to conventional non-selective anti-TNF therapeutics.