NRP2 and cancer: With regard to NRP2, studies have instead focused on annotating a role in cancer cells, where its upregulation is consistent with cancer progression in a number of cell types [e.g., neuroblastomas (Fakhari et al., 2002), non-small cell lung carcinoma [NSCLC] (Kawakami et al., 2002), human prostate carcinoma, melanoma (Bielenberg et al., 2004), lung cancer (Tomizawa et al., 2001; Kawakami et al., 2002; Lantuejoul et al., 2003), myeloid leukemia (Vales et al., 2007), breast cancer (Bachelder et al., 2001) and pancreatic cancer (Fukahi et al., 2004)].