NRP2 and cancer: NRP2 is known to regulate ECM adhesion and migration in various cell lines, including human ECs (Favier et al., 2006), immune cells (Curreli et al., 2007) and cancer cells (Kawakami et al., 2002; Fukahi et al., 2004; Caunt et al., 2008; Dallas et al., 2008; Cao et al., 2013).