In AML the molecular event related to the transfation ability of chromosomal translocation-generated AML fusion proteins (such as PML/RARa, PLZF/RARa, AML1-ETO, MLL/AF9) is strictly dependent on their capacity to induce abnormal epigenetic modification on genes relevant to the transformation process (Grignani et al., 1998; Di Croce et al., 2002; Fazi et al., 2007). The gene discussed is ZBTB16; the disease is acute myeloid leukemia.