Additionally, this group found that infection of colorectal or ovarian cancer cells with the approved oncolytic HSV did not stimulate the production of IFN-β in cell lines that were shown to be defective for STING, but did cause death in multiple cell lines (Xia et al., 2016; De Queiroz et al., 2019). This evidence concerns the gene STING1 and ovarian carcinoma.