STING1 and neoplasm: In support of a role for STING in the anti-tumor response, one group found that STING itself was down-regulated in multiple human colorectal and ovarian cancer cell lines, in addition to defects in cGAS (a cellular nucleotidyltransferase involved in the STING signaling pathway) and other stages of the STING pathway (Xia et al., 2016; De Queiroz et al., 2019).