The changes associated with EMT have been reported in keloid scars and involve the loss of epithelial cell markers such as E-cadherin (Ma et al., 2015; Yan et al., 2015; Hahn et al., 2016) and gain of mesenchymal characteristics such as vimentin and FSP-1 (fibroblast specific protein 1) expression (Yan et al., 2010, 2015; Ma et al., 2015; Hahn et al., 2016; Kuwahara et al., 2016), combined with changes in cell shape toward a more motile and migratory phenotype (Hahn et al., 2013, 2016; Supp et al., 2014; Stone et al., 2017). This evidence concerns the gene S100A4 and keloid.