Furthermore, by analyzing the expression of two essential partners of Ran involved in GTP loading (RCC1) and hydrolysis (RanGAP1), we found that while the RCC1 gene is clearly overexpressed in 16 of 18 studied cancers (Figure 1B), the dysregulation of RanGAP1 is cancer dependent (Figure 1C). This evidence concerns the gene RCC1 and cancer.