RAN and cancer: This data together with the many reports showing the overexpression of Ran in cancer cells (Azuma et al., 2004; Ouellet et al., 2005, 2006; Abe et al., 2008; Xia et al., 2008b; Yuen et al., 2012; Deng et al., 2014; Sheng et al., 2018) and our analysis (Figure 1A) showing that normal cells have lower Ran mRNA expression than cancer cells suggest that Ran would be a promising therapeutic target for several cancers.