RAN and cancer: Interestingly, by interrogating the Xena Functional Genomics Explorer, which allows the comparison of gene expression in tumors and normal tissues of several cancers1, we found that the expression of Ran was increased not only in the above mentioned cancers but also in all available cancer types, including brain, bladder, adrenal gland, thyroid, esophageal, uterine, liver, testicular, prostate, and cervical cancers (Figure 1A).