The deregulation of Ran in cancer has been reported in several tissue types (Azuma et al., 2004; Li et al., 2006; Ouellet et al., 2006; Xia et al., 2008b; Fan et al., 2013; Caceres-Gorriti et al., 2014; Matchett et al., 2014; Schnepp et al., 2015). Here, RAN is linked to cancer.