AKT1 and breast carcinoma: As for PI3K-Akt signaling pathway, it is actually one of the most famous tumor associated pathways, which has been identified to be pathogenic in multiple tumor subtypes, including breast cancer (Berns et al., 2007), B-cell lymphoma (Lannutti et al., 2011) and endocrine tumor (Robbins and Hague, 2016).