PUM1 can inhibit the proliferation of non-small-cell lung cancer cells via targeted by MiR-411-5p (Xia et al., 2018) and can mediate the interaction between p27 and MiR-221, which leads to the deterioration of non-small-cell lung cancer (Fernandez et al., 2015). Here, PUM1 is linked to non-small cell lung carcinoma.