IRF6 and nervous system neoplasm: For instance, we extract a rule (Rule 5 in Table 4) of methylation pattern for nervous system tumor, where IFFO1 (cg22203219), MARVED2 (cg16419724), ERICH1 (cg08454824), SFN (cg13466284), ELMO1 (cg16798247), and IRF6 (cg00989853) were identified as candidate signatures.